N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
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N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
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CAS No:
136450-06-1
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Formula:
C25H25NO4
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Chemical Name:
N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
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Synonyms:
Benzamide,N-(3-acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)-;N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide;3-[4-(4-Phenylbutoxy)benzoylamino]-2-hydroxyacetophenone;161369-32-0
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CAS No:
N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide Basic Attributes
403.47
403.47
416-150-9
66NXWRAG2B
DTXSID50275660
2924299090
Safety Information
53
61
P273, P501
H413
H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]|P273, and P501
N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide Use and Manufacturing
270 g of 4- (phenylbutoxy) benzoic acid was added, 270 g of thionyl chloride was added and incubated at 50 ° C for 3 hours. After completion of the reaction, the unreacted thionyl chloride was recovered under reduced pressure. Nitrogen blowing into the thiophene chloride. Cooled to room temperature by adding 270 g of dichloromethane. Weigh 151 g of 3-amino-2-hydroxyacetophenone in 200 g of methylene chloride, 160 g of pyridine was added, and a solution of 4- (phenylbutoxy) benzoyl chloride in methylene chloride was added dropwise to the ice bath. The temperature is not more than 10 , dripping finished, 10 incubation reaction 2h, after the end of the reaction, adding to the reaction system dilute hydrochloric acid, adjust the pH to 2-3, liquid, methyl chloride layer washed to neutral, anhydrous Dried over sodium sulfate, filtered and concentrated to give a reddish brown solid, petroleum ether: ethyl acetate = 1: 1 recrystallization to give 334 g, yield 84percent.
Computed Properties
Molecular Weight:403.5
XLogP3:5.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:403.17835828
Monoisotopic Mass:403.17835828
Topological Polar Surface Area:75.6
Heavy Atom Count:30
Complexity:537
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
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