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(±)-Aegeline

(±)-Aegeline structure

CAS No:
456-12-2
Formula:
C18H19NO3
Chemical Name:
(±)-Aegeline
Synonyms:
2-Propenamide,N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-,(2E)-;Egeline;2-Propenamide,N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-,(E)-(±)-;(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide;Aegelin;Aegeline;(±)-Egeline;(±)-Aegeline;2-Propenamide,N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-,(E)-;37791-13-2
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Solid

OxyELITE Pro is the commercial name for a variety of multi-ingredient dietary supplements (MIDS) marketed for weight loss and body building. In 2013, one of the OxyELITE Pro products called “Super Thermogenic” was withdrawn from use in the United States after it was implicated in more than 50 cases of acute hepatitis including several instances of fatal, acute liver failure.

(±)-Aegeline Basic Attributes

Molecular Weight：

297.34836

Exact Mass：

297.35

EC Number：

1533716-785-6

HScode：

2924299090

Characteristics

PSA：

58.6

XLogP3：

2.4

Appearance：

Solid

Density：

1.2±0.1 g/cm3

Melting Point：

178-179 °C

Boiling Point：

567.6°C at 760 mmHg

Flash Point：

297.1±30.1 °C

Refractive Index：

1.612

Toxicity

Hepatotoxicity：

OxyELITE Pro has been associated with at least 50 instances of clinically apparent acute liver injury. The onset of injury was usually within 2 to 20 weeks of starting regular use or of switching to the altered formulation of OxyELITE Pro products. The typical presenting symptoms were fatigue, nausea, and abdominal pain followed by dark urine and jaundice. The pattern of liver injury was hepatocellular and serum aminotransferase levels ranged to as high as several thousand U/L while alkaline phosphatase levels tended to be normal or minimally elevated (less than 3 times ULN). Liver biopsies showed an acute hepatitis-like picture and severe cases were associated with confluent, submassive or massive necrosis. Immunoallergic and features were not common, but autoantibodies were often detected. Indeed, instances of an autoimmune hepatitis-like pattern of injury occurred in a proportion of cases, some of which led to a chronic hepatitis and required long term immune suppressive therapy despite prompt withdrawal of the agent. The mortality rate overall was approximately 10% among cases with jaundice. In most non-fatal cases, symptoms resolved within 1 to 8 weeks and laboratory tests returned to normal by two to three months.

Drug Information

LiverTox Summary：

Drug Classes：

Herbal and Dietary Supplements

MeSH Entry Terms：

aegeline

(±)-Aegeline Use and Manufacturing

Aegeline, is a compound that can be extracted from Aegle marmelos leaves, a tree that grows in India. Research has found the essential oil of the tree to be effective against 21 types of bacteria. Aegeline, has also shown to have anti-obesity effects.

Computed Properties

Molecular Weight:297.3
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:297.13649347
Monoisotopic Mass:297.13649347
Topological Polar Surface Area:58.6
Heavy Atom Count:22
Complexity:355
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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DAHAI BIOCHEM LTD Contact Supplier

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Unit Price: $28 /KG EXW

CAS No.: 456-12-2

Grade: Pharma Grade

Content: 99%

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Manufactory Supplier of Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5,Ginsenoside Rg5,Ginsenoside Rh2,Protopanaxatriol,Epmedin C,Icariin,Icaritin,Baohuoside I,Total Ginsenosides,Total Ginsenosides from Ginseng Stems And Leaves,Oridonin,Oleuropein,Curcumin,(20)-Ginsenoside Rg3,(20)-Protopanaxadiol

Aegeline

Unit Price: $2500-2550 /KG EXW

CAS No.: 456-12-2

Grade: Industrial Grade

Content: 98%

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