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A-3 HYDROCHLORIDE

A-3 HYDROCHLORIDE structure

CAS No:
78957-85-4
Formula:
C12H14Cl2N2O2S
Chemical Name:
A-3 HYDROCHLORIDE
Synonyms:
A-3 HYDROCHLORIDE;A-3;N-(2-AMINOETHYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HCL;N-(2-AMINOETHYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE;N-(2-AMINOETHYL)-5-CHLORONAPHTHALENE-1-SULPHONAMIDE HYDROCHLORIDE;N-(2-AMINOETHYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;TRISIALYLATED, GALACTOSYLATED, TRIANTENNARY

Description

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1].

A-3 HYDROCHLORIDE Basic Attributes

Molecular Weight：

321.22

Exact Mass：

320.01500

Characteristics

PSA：

80.57000

XLogP3：

4.70420

Appearance：

white solid

Melting Point：

173-176°C

Water Solubility：

DMSO: 24 mg/mL

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

A-3 HYDROCHLORIDE Use and Manufacturing

Inhibits cAMP and cGMP dependent protein kinases.Also inhibits MLC kinase and protein kinase C

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Guide of A-3 HYDROCHLORIDE

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Learn More Other Chemicals

A-3 HYDROCHLORIDE

SDS

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