(6α,11β)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione
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(6α,11β)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione
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CAS No:
23641-05-6
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Formula:
C25H30F2O7
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Chemical Name:
(6α,11β)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione
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Synonyms:
Pregna-1,4-diene-3,20-dione,17,21-bis(acetyloxy)-6,9-difluoro-11-hydroxy-,(6α,11β)-;Pregna-1,4-diene-3,20-dione,6α,9-difluoro-11β,17,21-trihydroxy-,17,21-diacetate;(6α,11β)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione
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CAS No:
(6α,11β)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione Basic Attributes
513.5050464
480.50
245-799-9
(6α,11β)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione Use and Manufacturing
11α, 17α, 21-trihydroxypregna-4-ene-3, 20-dione (ie epihydrocortisone) can be acetylated (21-hydroxyl), (11-hydroxyl) sulfonylated and combined Eliminate [form 9(11)-double bond], (17α-hydroxyl and 3-keto) acetylation (convert 4-position double bond into 3-position and 5-position double bond), (6β-position) fluorine Chemical and hydrolysis (removal of the 3-position acetyl group), (3-position and 5-position double bonds back to 3-position keto group and 4-position double bond), (6β-fluoro) translocation, [9(11) -Double bond) epoxidation, (hydrogen fluoride on epoxy group) addition (introduction of 11β-hydroxy- and 9α-fluorine), dehydrogenation (formation of 1-position double bond).
Intermediate of Acetyl Acetate.
(6α,11β)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione
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