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2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6)

2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6) structure

CAS No:
185991-07-5
Formula:
C24H38N6.6BrH
Chemical Name:
2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6)
Synonyms:
2-Pyridinemethanamine,N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-,hydrobromide (1:6);2-Pyridinemethanamine,N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-,hexahydrobromide;AMD 3465;GENZ 644494

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Description

AMD 3465 hexahydrobromide is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6) Basic Attributes

Molecular Weight：

410.59872

Exact Mass：

889.872742

Characteristics

PSA：

64.25000

XLogP3：

8.79980

Density：

1.022g/cm3

Boiling Point：

571.3ºC at 760 mmHg

Flash Point：

299.3ºC

Refractive Index：

1.533

Vapor Pressure：

5.1E-13mmHg at 25°C

2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6) Use and Manufacturing

AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma

Recommended Suppliers of 2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6)

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N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

CAS No.: 185991-07-5

Content: 99.00%

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Guide of 2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6)

Description
Basic Attributes
Characteristics
Use and Manufacturing
Recommended Suppliers

2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6)

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