AMG 487
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AMG 487
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CAS No:
473719-41-4
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Formula:
C32H28F3N5O4
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Chemical Name:
AMG 487
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Synonyms:
AMG 487;AMG-487;AMG487;N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido(2,3-d)pyrimidin-2-yl)ethyl)-N-pyridin-3-ylmethyl-2-(4-trifluoromethoxyphenyl)acetamide;UNII-355CGR2CBL;355CGR2CBL;CHEMBL397983;SCHEMBL335753
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CAS No:
Description
AMG 487 is an antagonist of chemokine receptor 3 CXCR3 which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
Computed Properties
Molecular Weight:603.6
XLogP3:5.2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:603.20933888
Monoisotopic Mass:603.20933888
Topological Polar Surface Area:97.2
Heavy Atom Count:44
Complexity:997
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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AMG 853 Formula
1169483-24-2
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AST 487 Formula
630124-46-8