3-Amino-6-bromopyrazine-2-carboxamide

12 g of 3-aminopyrazine-2-carboxamide was added to 150 ml of acetic acid, 19 g of bromoform was slowly added, and the mixture was heated under reflux and stirred for 3 hours. The mixture was concentrated, water and ethyl acetate were added for extraction, concentrated, and the residue was applied to a silica gel column. 10 g of 3-amino-6-bromopyrazine-2-carboxamide was isolated.10 g of In the equipped with magnetic stirring, of the reflux condensation tube (with drying tail pipe) of 250 ml in three-necked bottle, adding 13.1g (about 0.06 muM) 3 - amino pyrazine -2 - formamide, 60 ml of acetic anhydride, 60 ml ethyl trimethyl orthoformate, stirring under heating to reflux 4h, started when the reflux temperature 136 C, gradually reduced to 95 C, cooling to room temperature, filter, ice laundering, a brown solid.The crude isopropyl alcohol and water (1:1) about 300 ml of mixed the fluid is heavy crystallization, heating completely dissolved, add 2g activated carbon to decolorize 30min, heat filtering, washing. Cooling separating white solid. 60 C drying. Be 11.24g white powder that is 6 - bromo -4 (3H) dihydropteridinones. Yield: 82.5To a lOOmI flask was added

Molecular Weight:217.02
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:215.96467
Monoisotopic Mass:215.96467
Topological Polar Surface Area:94.9
Heavy Atom Count:11
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes