Xipamide

Off-White Solid

Xipamide is a member of benzamides.|Xipamide is a sulfonamide-based diuretic. Xipamide acts on the distal convoluted tubules. In addition, this agent has a weak inhibitory effect on carbonic anyydrase (CA).|A sulfamoylbenzamide analog of CLOPAMIDE. It is diuretic and saluretic with antihypertensive activity. It is bound to PLASMA PROTEINS, thus has a delayed onset and prolonged action.

General procedure: The complexes [Ti(XPD)2(H2O)2]Cl (1), [Ni(XPD)2(H2O)2] (2), [ZrO(XPD)2H2O]·H2O (2), [Pd(XPD)2(H2O)2]·H2O(4), [Ce(XPD)2SO4] (5), and [UO2(XPD)2]·3H2O (6) were synthesized as follows: 0.5 mmol of the corresponding metal salt, TiCl3, NiSO4·6H2O, ZrOCl2·8H2O, PdCl2, Ce(SO4)2, or UO2(NO3)2·6H2O, was dissolved in 20 mL of bidistilled water and added to 1mmol (0.35 g) of XPD and 1 mmol (0.40 g) of NaOHin 25 mL of acetone. The mixture was stirred at room temperature for 3 days, and then left for slow evaporation. The formed precipitates were filtered off, washed several times with bidistilled water, and dried over CaCl2 in a desiccator under vacuum.General procedure: The complexes [Ti(XPD)2(H2O)2]Cl (1), [Ni(XPD)2(H2O)2] (2), [ZrO(XPD)2H2O]·H2O (2), [Pd(XPD)2(H2O)2]·H2O(4), [Ce(XPD)2SO4] (5), and [UO2(XPD)2]·3H2O (6) were synthesized as follows: 0.5 mmol of the corresponding metal salt, TiCl3, NiSO4·6H2O, ZrOCl2·8H2O, PdCl2, Ce(SO4)2, or UO2(NO3)2·6H2O, was dissolved in 20 mL of bidistilled water and added to 1mmol (0.35 g) of XPD and 1 mmol (0.40 g) of NaOHin 25 mL of acetone. The mixture was stirred at room temperature for 3 days, and then left for slow evaporation. The formed precipitates were filtered off, washed several times with bidistilled water, and dried over CaCl2 in a desiccator under vacuum.General procedure: The complexes [Ti(XPD)2(H2O)2]Cl (1), [Ni(XPD)2(H2O)2] (2), [ZrO(XPD)2H2O]·H2O (2), [Pd(XPD)2(H2O)2]·H2O(4), [Ce(XPD)2SO4] (5), and [UO2(XPD)2]·3H2O (6) were synthesized as follows: 0.5 mmol of the corresponding metal salt, TiCl3, NiSO4·6H2O, ZrOCl2·8H2O, PdCl2, Ce(SO4)2, or UO2(NO3)2·6H2O, was dissolved in 20 mL of bidistilled water and added to 1mmol (0.35 g) of XPD and 1 mmol (0.40 g) of NaOHin 25 mL of acetone. The mixture was stirred at room temperature for 3 days, and then left for slow evaporation. The formed precipitates were filtered off, washed several times with bidistilled water, and dried over CaCl2 in a desiccator under vacuum.General procedure: The complexes [Ti(XPD)2(H2O)2]Cl (1), [Ni(XPD)2(H2O)2] (2), [ZrO(XPD)2H2O]·H2O (2), [Pd(XPD)2(H2O)2]·H2O(4), [Ce(XPD)2SO4] (5), and [UO2(XPD)2]·3H2O (6) were synthesized as follows: 0.5 mmol of the corresponding metal salt, TiCl3, NiSO4·6H2O, ZrOCl2·8H2O, PdCl2, Ce(SO4)2, or UO2(NO3)2·6H2O, was dissolved in 20 mL of bidistilled water and added to 1mmol (0.35 g) of XPD and 1 mmol (0.40 g) of NaOHin 25 mL of acetone. The mixture was stirred at room temperature for 3 days, and then left for slow evaporation. The formed precipitates were filtered off, washed several times with bidistilled water, and dried over CaCl2 in a desiccator under vacuum.General procedure: The complexes [Ti(XPD)2(H2O)2]Cl (1), [Ni(XPD)2(H2O)2] (2), [ZrO(XPD)2H2O]·H2O (2), [Pd(XPD)2(H2O)2]·H2O(4), [Ce(XPD)2SO4] (5), and [UO2(XPD)2]·3H2O (6) were synthesized as follows: 0.5 mmol of the corresponding metal salt, TiCl3, NiSO4·6H2O, ZrOCl2·8H2O, PdCl2, Ce(SO4)2, or UO2(NO3)2·6H2O, was dissolved in 20 mL of bidistilled water and added to 1mmol (0.35 g) of XPD and 1 mmol (0.40 g) of NaOHin 25 mL of acetone. The mixture was stirred at room temperature for 3 days, and then left for slow evaporation. The formed precipitates were filtered off, washed several times with bidistilled water, and dried over CaCl2 in a desiccator under vacuum.General procedure: The complexes [Ti(XPD)2(H2O)2]Cl (1), [Ni(XPD)2(H2O)2] (2), [ZrO(XPD)2H2O]·H2O (2), [Pd(XPD)2(H2O)2]·H2O(4), [Ce(XPD)2SO4] (5), and [UO2(XPD)2]·3H2O (6) were synthesized as follows: 0.5 mmol of the corresponding metal salt, TiCl3, NiSO4·6H2O, ZrOCl2·8H2O, PdCl2, Ce(SO4)2, or UO2(NO3)2·6H2O, was dissolved in 20 mL of bidistilled water and added to 1mmol (0.35 g) of XPD and 1 mmol (0.40 g) of NaOHin 25 mL of acetone. The mixture was stirred at room temperature for 3 days, and then left for slow evaporation. The formed precipitates were filtered off, washed several times with bidistilled water, and dried over CaCl2 in a desiccator under vacuum.

Xipamide is a diuretic and antihypertensive agent.

Molecular Weight:354.8
XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:354.0441058
Monoisotopic Mass:354.0441058
Topological Polar Surface Area:118
Heavy Atom Count:23
Complexity:526
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes