2-amino-2-(1,2,3,4-tetrahydronaphthalen-1-yl)acetic acid

Boc-1-Tetralinylglycine was prepared starting from 1, 2-dihydronaphthalene. 1, 2-Dihydronaphthalene was initially converted into 1-tetralyl bromide with HBr (similar to J. Med. Chem. 37 (1994) 1586). The bromide was subsequently reacted with diethyl acetamidomalonate and, after hydrolytic cleavage, the resulting alpha-amino acid was converted into the Boc-protected form under standard conditions. Another possible preparation is described by E. Reimann and D. Voss (E. Reimann, D. Voss, Arch. Pharm. 310 (1977) 102).Boc-1-Tetralinylglycine was prepared starting from 1, 2-dihydronaphthalene. 1, 2-Dihydronaphthalene was initially converted into 1-tetralyl bromide with HBr (similar to J. Med. Chem. 37 (1994) 1586). The bromide was subsequently reacted with diethyl acetamidomalonate and, after hydrolytic cleavage, the resulting alpha-amino acid was converted into the Boc-protected form under standard conditions. Another possible preparation is described by E. Reimann and D. Voss (E. Reimann, D. Voss, Arch. Pharm. 310 (1977) 102)

Molecular Weight:205.25
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:205.110278721
Monoisotopic Mass:205.110278721
Topological Polar Surface Area:63.3
Heavy Atom Count:15
Complexity:242
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes