2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
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![2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/542703f11c084656afaeebba2cd0a48c.png "2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one")
2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
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CAS No:
27277-00-5
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Formula:
C9H13N5O
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Chemical Name:
2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
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Synonyms:
[1,2,4]Triazolo[1,5-a]pyrimidin-5(4H)-one,2-amino-6-methyl-4-propyl-;s-Triazolo[1,5-a]pyrimidin-5(4H)-one,2-amino-6-methyl-4-propyl-;2-Amino-6-methyl-4-propyl[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one;2-Amino-6-methyl-4-propyl-s-triazolo[1,5-a]pyrimid-5(4H)-one;2-Amino-6-methyl-5-oxo-4-propyl-4,5-dihydro-s-triazolo[1,5-a]pyrimidine;ICI 63197;2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo[1,5-a]pyrimidin-5-one;2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-Amino-6-methyl-4-propyl-4H,5H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;33406-42-7
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CAS No:
Description
2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one is a member of triazolopyrimidines.
2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Basic Attributes
207.23
207.23
248-383-5
015G4I43YD
DTXSID6041391
2933990090
Characteristics
77
0.6
white solid
1.44g/cm3
161.8-163 °C
459.9°C at 760 mmHg
231.9ºC
1.696
DMSO: 13 mg/mL
Store at +4°C
1.22E-08mmHg at 25°C
Safety Information
III
6.1(b)
2811
1
P264, P270, P301+P310, P321, P330, P405, P501
H301
|Danger|H301 (97.8%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 91 companies from 2 notifications to the ECHA C&L Inventory.
2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Use and Manufacturing
2-amino-6-methyl-[1, 2, 4]-triazolo[1, 5-a]pyrimidin-5-one 165 g (1 mol) and propyl bromide 184 g (1.5 mol) were added to the reaction apparatus , Triethylamine (101g, 1mol) and chloroform (900ml) were added and the temperature was raised to 65 °C for 6h. HPLC detection2-amino-6-methyl-[1, 2, 4]-triazolo[1, 5-a]pyrimidin-5-one < 0.5percent, After the end of the reaction; distillation (50 ° C) recovery of chloroform, the residue added to 830mlEthyl acetate and 330 ml water, stirring to separate the ethyl acetate phase, Ethyl acetate (500ml) was distilled off, crystallized, filtered, and cake was washedAfter washing (with water until the washing liquid is neutral), Dry (about 70 °C dry to constant weight), get2-amino-6-methyl-4-n-propyl-[1, 2, 4]-triazolo[1, 5-a]pyrimidin-5-one176g, yield 85percent, purity 99percent.
[1,2,4]Triazolo[1,5-a]pyrimidin-5(4H)-one, 2-amino-6-methyl-4-propyl-: ACTIVE
Computed Properties
Molecular Weight:207.23
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:207.11201006
Monoisotopic Mass:207.11201006
Topological Polar Surface Area:77
Heavy Atom Count:15
Complexity:303
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Amino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
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