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Home > Encyclopedia > Riluzole hydrochloride

Riluzole hydrochloride

Riluzole hydrochloride structure

Riluzole hydrochloride 

structure
  • CAS No:

    850608-87-6

  • Formula:

    C8H6ClF3N2OS

  • Chemical Name:

    Riluzole hydrochloride

  • Synonyms:

    Riluzole hydrochloride;850608-87-6;2-Amino-6-trifluoromethoxybenzothiazole hydrochloride;SMR000449311;SR-01000002997;Prestwick_644;CPD000449311;Riluzole (hydrochloride);MLS000758261;MLS001424008

Riluzole hydrochloride Basic Attributes

270.66

269.984

Characteristics

76.4

Riluzole hydrochloride Use and Manufacturing

Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Riluzole has been explored as a therapeutic for slowing disease progression of amyotrophic lateral sclerosis.

Computed Properties

Molecular Weight:270.66
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:269.9841462
Monoisotopic Mass:269.9841462
Topological Polar Surface Area:76.4
Heavy Atom Count:16
Complexity:238
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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