4-Amino-2,2,6,6-tetramethylpiperidine
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4-Amino-2,2,6,6-tetramethylpiperidine
structure -
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CAS No:
36768-62-4
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Formula:
C9H20N2
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Chemical Name:
4-Amino-2,2,6,6-tetramethylpiperidine
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Synonyms:
4-Piperidinamine,2,2,6,6-tetramethyl-;2,2,6,6-Tetramethyl-4-piperidinamine;4-Amino-2,2,6,6-tetramethylpiperidine;2,2,6,6-Tetramethyl-4-aminopiperidine;2,2,6,6-Tetramethyl-4-piperidylamine;Triacetonediamine;NSC 102510;118326-87-7;2434633-51-7
- Categories:
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CAS No:
4-Amino-2,2,6,6-tetramethylpiperidine Basic Attributes
156.27
156.27
253-197-2
ETF220Q65R
102510
DTXSID3044388
29333999
Characteristics
38
0.6
Liquid
0.8966 g/cm3 @ Temp: 20 °C
17 °C
188.5 °C
162 °F
1.433
H2O: soluble
Store below +30°C.
<=20 hPa (20 °C)
LD50 orally in Rabbit: 1000 mg/kg
Safety Information
III
8
UN 2735 8/PG 3
2
22-36/37/38-34-52/53-41
26-36/37-45-36/37/39-61
TM4290100
Xn,Xi,C
Irritant
Stable at room temperature in closed containers under normal storage and handling conditions.
P273-P280-P305 + P351 + P338-P310
H290-H302-H314-H412
|Danger|H290 (26.32%): May be corrosive to metals [Warning Corrosive to Metals]|P234, P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P390, P404, P405, and P501|Aggregated GHS information provided by 171 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-Amino-2,2,6,6-tetramethylpiperidine Use and Manufacturing
12300 g of 2, 2, 6, 6-tetramethylpiperidine-4-one, deionized water and 11 g of the catalyst were initially introduced under argon in a 1 l stirred autoclave with a paddle stirrer, electric heating, air cooling and a hydrogen mass through-flow regulator. The catalysts used were firstly B113W (active metal nickel) and secondly B2112Z (active metal cobalt) from Evonik Degussa GmbH. The autoclave was then flushed three times with nitrogen. The stirrer was set at a rotational speed of 300 rpm. Then, 83 g of liquid ammonia were metered in. Then, with the help of hydrogen, the pressure was set at the desired pressure of the main reaction and also the temperature. The after-reaction takes place at a temperature of 150° C. and a pressure of 50 bar for about 3 hours. Conditions for the after-reaction deviating from these were noted in Table 1 below. Table 1 shows both the process parameters, and also the results of the examples carried out.EXAMPLE 3 EXAMPLE 6 EXAMPLE 4 EXAMPLE 7 Examples 1-12300 g of 2, 2, 6, 6-tetramethylpiperidine-4-one, deionized water and 11 g of the catalyst were initially introduced under argon in a 1 l stirred autoclave with a paddle stirrer, electric heating, air cooling and a hydrogen mass through-flow regulator. The catalysts used were firstly B113W (active metal nickel) and secondly B2112Z (active metal cobalt) from Evonik Degussa GmbH. The autoclave was then flushed three times with nitrogen. The stirrer was set at a rotational speed of 300 rpm. Then, 83 g of liquid ammonia were metered in. Then, with the help of hydrogen, the pressure was set at the desired pressure of the main reaction and also the temperature. The after-reaction takes place at a temperature of 150° C. and a pressure of 50 bar for about 3 hours. Conditions for the after-reaction deviating from these were noted in Table 1 below. Table 1 shows both the process parameters, and also the results of the examples carried out.
Triacetonediamine have been investigated as new anticancer drugs with high activity and low toxicity.
Intermediates
Plastic and rubber products not covered elsewhere
All other chemical product and preparation manufacturing|4-Piperidinamine, 2,2,6,6-tetramethyl-: ACTIVE
Computed Properties
Molecular Weight:156.27
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:156.162648646
Monoisotopic Mass:156.162648646
Topological Polar Surface Area:38
Heavy Atom Count:11
Complexity:134
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4-Amino-2,2,6,6-tetramethylpiperidine
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