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Remacemide hydrochloride

Remacemide hydrochloride structure

CAS No:
111686-79-4
Formula:
C17H20N2O.ClH
Chemical Name:
Remacemide hydrochloride
Synonyms:
Acetamide,2-amino-N-(1-methyl-1,2-diphenylethyl)-,hydrochloride (1:1);Acetamide,2-amino-N-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(±)-;Acetamide,2-amino-N-(1-methyl-1,2-diphenylethyl)-,monohydrochloride;FPL 12924AA;PR 934-423A;Remacemide hydrochloride;2-Amino-N-(1,2-diphenylpropan-2-yl)acetamide hydrochloride;118754-06-6

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Remacemide hydrochloride Basic Attributes

Molecular Weight：

304.81

Exact Mass：

304.13400

DSSTox ID：

DTXSID9045683

HScode：

2924299090

Characteristics

PSA：

55.1

XLogP3：

4.11260

Appearance：

white to beige

Melting Point：

253-254°

Boiling Point：

466.4ºC at 760mmHg

Flash Point：

235.9ºC

Water Solubility：

H2O: >10mg/mL

Storage Conditions：

Desiccate at RT

Vapor Pressure：

7.09E-09mmHg at 25°C

Toxicity：

LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer)

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

22-41-50/53

safety instructions：

26-39-45-60-61

RTECS Number：

AB4349500

Marks：

Xn,N

Precautionary statement(s)：

P273-P280-P305 + P351 + P338

Hazard Statements：

H302-H318-H400

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P305+P351+P338, P310, P330, P391, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

MeSH Entry Terms：

2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide

Remacemide hydrochloride Use and Manufacturing

Anticonvulsant (neuroprotective).Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8-68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM).

Computed Properties

Molecular Weight:304.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:304.1342410
Monoisotopic Mass:304.1342410
Topological Polar Surface Area:55.1
Heavy Atom Count:21
Complexity:306
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of Remacemide hydrochloride

Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

Remacemide hydrochloride

SDS

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