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4-Amino-2-chloropyridine

4-Amino-2-chloropyridine structure

CAS No:
14432-12-3
Formula:
C5H5ClN2
Chemical Name:
4-Amino-2-chloropyridine
Synonyms:
4-Pyridinamine,2-chloro-;Pyridine,4-amino-2-chloro-;2-Chloro-4-pyridinamine;4-Amino-2-chloropyridine;2-Chloro-4-aminopyridine;(2-Chloropyridin-4-yl)amine;2-Chloropyridin-4-amine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

White powder.4-Amino-2-chloropyridine is an important pharmaceutical and pesticide intermediate. It can synthesize N-(2-chloro-4-pyridyl)urea regulators that promote plant growth. It is also a key substance in the synthesis of KT-30 (Forchlorfenuron, IUPAC name N-(2-chloro-4-pyridyl)-N'-phenylurea). KT-30 is a highly active cytokinin, which has the biological activity of promoting tissue growth, promoting bud development and green preservation; it has an effect of increasing yield on apple, pea

4-Amino-2-chloropyridine is an aminopyridine.

4-Amino-2-chloropyridine Basic Attributes

Molecular Weight：

128.56

Exact Mass：

128.56

BRN：

108671

EC Number：

238-403-0

UNII：

BHC29VF8KH

DSSTox ID：

DTXSID20162674

HScode：

29333999

Characteristics

PSA：

38.9

XLogP3：

1.1

Appearance：

Light yellow Crystalline Powder

Density：

1.2417 (rough estimate)

Melting Point：

91-91.5 °C

Boiling Point：

153°C5mm

Flash Point：

153°C/5mm

Refractive Index：

1.5110 (estimate)

Water Solubility：

Slightly soluble in water.

Storage Conditions：

Store in a cool, dry place. Store in a tightly closed container.

Vapor Pressure：

0.00116mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

2811

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-37/39-36/37/39

Marks：

Hazard note：

Irritant

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H302 (15.69%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 51 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-Amino-2-chloropyridine Use and Manufacturing

Methods of Manufacturing

The preparation method uses isonicotinic acid as a raw material, chlorination with phosphorus oxychloride to obtain 2-chloropyridine-4-carboxylic acid, and then reacts with ammonia gas to form a corresponding amide, and then undergoes Huffman degradation reaction to obtain a product . You can also use 2-chloropyridine-N-oxide as the raw material, first nitrate with fuming nitric acid, and then reduce it with iron powder in acetic acid to obtain the product.

Uses

An aminopyridine derivative with potential herbicidal activity.

Computed Properties

Molecular Weight:128.56
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:128.0141259
Monoisotopic Mass:128.0141259
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:76.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Nitric acid

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