2-AMINO-4-CHLORO-6-NITROTOLUENE

The starting material 4a (5.9g, 23.60mmol) in methanol (10mL) 1, 4-dioxane (5mL) was dissolved, 10N HCl (12 mL) Fe (3.96 g, 70.80 mmol) was added under ice-cooling, and the mixture was stirred at 80 ° C for 3 h.TLC showed the starting material to react completely.Finally, 3.55 g of pale yellow powder was obtained, yield: 68.4percent.The starting material 4a (5.9 g, 23.60 mmol) was dissolved in methanol (10 mL) hexanes (5 mL).10N HCl (12 mL) Fe (3.96 g, 70.80 mmol) was added under ice bath.After the addition, stirring at 80 ° C for 3 h, TLC showed that the starting material was completely reacted. Finally, 3.55 g of pale yellow powder was obtained, yield: 68.4percent.Step B:

Molecular Weight:186.59
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:186.0196052
Monoisotopic Mass:186.0196052
Topological Polar Surface Area:71.8
Heavy Atom Count:12
Complexity:183
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes