2-Aminomethylphenylacetic acid

wherein a selection of useful peptidomimetic elements are the following:...4-(2-aminoethyl)-6-dibenzofuranpropionic acid (Aedfp)(R, S)-1-aminoindane-1-carboxylic acid (1-Aic)2-aminoindane-2-carboxylic acid (2-Aic)2'-(aminomethyl)-biphenyl-2-carboxylic acid (Ambc)2-(2-((2-(4-((1H-pyrazol-1-yl)methyl)benzyl)-2H-pyrazolo[3, 4-d]pyrimidin-4-ylamino)methyl)phenyl)acetic acidInto a 8-mL vial, was placed a solution of 2-(4-((1H-pyrazol-1-yl)methyl)benzyl)-4-chloro-2H-pyrazolo[3, 4-d]pyrimidine (537 mg, 1.65 mmol, 1.00 equiv)(Example 23) in N, N-dimethylformamide (5 mL), General procedure: Thepromoiety capped model peptide was dissolved at 1 mg/mLconcentration in PBS and the solutionwas incubated at 37°C in a water bath.Samples werecollected for analysisat different time points (e.g., 8h, 16h, 24h, 48h, 72h, 96h, 120h).If the half life of a promoietycapped model peptideis significantly longeror shorter, the time framefor sampling analysiswould be changedaccordingly. The promoiety cleavage was quenchedby lowering pH to 2 by additionof 0.1percent TFA solution.RP-HPLC was used to monitorthe cleavage reactions and the cleavage rates were quantitatively studied by measuringthe peak areas of the promoiety capped and released model peptides.Agilent 6110 Quadrupole LC-MS wasemployed to verifythe change of massin the course of reaction.

Molecular Weight:165.19
XLogP3:-1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:165.078978594
Monoisotopic Mass:165.078978594
Topological Polar Surface Area:63.3
Heavy Atom Count:12
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes