2-Aminophenoxazin-3-one
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2-Aminophenoxazin-3-one
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CAS No:
1916-59-2
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Formula:
C12H8N2O2
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Chemical Name:
2-Aminophenoxazin-3-one
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Synonyms:
3H-Phenoxazin-3-one,2-amino-;2-Amino-3H-phenoxazin-3-one;Questiomycin A;2-Aminophenoxazin-3-one;2-Aminophenoxazon;2-Amino-3-phenoxazone;2-Aminophenoxazone;AV Toxin C;Acrospermumviticola toxin C;NSC 94945;Isophenoxazine
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CAS No:
Characteristics
64.7
1
1.2399 (rough estimate)
249-250 °C
352.04°C (rough estimate)
1.6000 (estimate)
4.035e+004 mg/L @ 25 °C (est)
Safety Information
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 90 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Aminophenoxazin-3-one Use and Manufacturing
Questiomycin A is a phenoxazine produced by several Streptomyces species and some fungi and bacteria. Questiomycin A is weakly active against bacteria, fungi, plants and tumor cell lines, and inhibits aromatase and sulfatases. Questiomycin, like other phenoxazines, stimulates cell growth and turnover in vitro, an activity possibly related to their ability to form stable free radicals. More recently, questiomycin A has been shown to inhibit pulmonary metastasis caused by mouse melanoma cells. Questiomycin A and related phenoxazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.