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Anagliptin

Anagliptin structure

CAS No:
739366-20-2
Formula:
C19H25N7O2
Chemical Name:
Anagliptin
Synonyms:
Pyrazolo[1,5-a]pyrimidine-6-carboxamide,N-[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methyl-;N-[2-[[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide;Anagliptin;Suiny;N-[2-([2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Anagliptin is a highly selective, potent inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8/9 (IC50, 68, 60 nM, respectively).

Anagliptin is an amino acid amide.|Anagliptin is under investigation for the treatment of LDL Cholesterol, Coronary Disease, Diabetes Mellitus, Glycosylated Hemoglobin, and Dipeptidyl-Peptidase 4 Inhibitors.|Anagliptin is an orally available, potent, selective inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Compared to vildagliptin, anagliptin caused longer lasting inhibition of DPP-4 activity.

Anagliptin Basic Attributes

Molecular Weight：

383.4475

Exact Mass：

383.45

UNII：

K726J96838

NCI Thesaurus Code：

C96202

Characteristics

PSA：

115

XLogP3：

-0.34

Density：

1.3±0.1 g/cm3

Refractive Index：

1.661

Drug Information

MeSH：

Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)

MeSH Entry Terms：

(S)-N-(2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)-2-methylpyrazolo(1,5-a)pyrimidine-6-carboxamide

Computed Properties

Molecular Weight:383.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:383.20697307
Monoisotopic Mass:383.20697307
Topological Polar Surface Area:115
Heavy Atom Count:28
Complexity:643
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes