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ALX 0600

ALX 0600 structure

CAS No:
197922-42-2
Formula:
C164H252N44O55S
Chemical Name:
ALX 0600
Synonyms:
ALX 0600;Gattex;Glucagon-like peptide II [2-glycine] (human);Teduglutide
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ChEBI: A 33-membered polypeptide consisting of His, Gly, Asp, Gly, Ser, Phe, Ser, Asp, Glu, Met, Asn, Thr, Ile, Leu, Asp, Asn, Leu, Ala, Ala, Arg, Asp, Phe, Ile, Asn, Trp, Leu, Ile, Gln, Thr, Lys, Ile, Thr and Asp residues joined in sequence. A glucagon-like pep ide-2 receptor agonist used for the treatment of short-bowel syndrome.Teduglutide was approved in August 2012 by the European Commission and in December 2012 by the US FDA for the treatment of adults with short bowel syndrome (SBS) wh

ALX 0600 Basic Attributes

Molecular Weight：

3752.133

Exact Mass：

3749.80000

Characteristics

PSA：

1650

XLogP3：

1.01630

Storage Conditions：

Store refrigerated at 2 deg C to 8 deg C (36 deg F to 46 deg F) for Cartons of Drug Vials and the One-vial kits. Do not freeze. Do not use beyond the expiration date on the label. Store at room temperature up to 25 deg C (77 deg F) for the Cartons of Ancillary Supplies.

ALX 0600 Use and Manufacturing

Treatment of intestinal diseases characterized by chemical or surgical damage of the intestinal epithelium such as Short Bowel Syndrome (SBS) or damage to the intestinal epithelium due to disease (glucagon-like peptide-2 (GLP- 2) analog).

Computed Properties

Molecular Weight:3752.1
XLogP3:-15.2
Hydrogen Bond Donor Count:55
Hydrogen Bond Acceptor Count:60
Rotatable Bond Count:126
Exact Mass:3750.8028943
Monoisotopic Mass:3749.7995395
Topological Polar Surface Area:1650
Heavy Atom Count:264
Complexity:9030
Defined Atom Stereocenter Count:38
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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