Amsacrine hydrochloride

429.92

429.09100

257-094-3

U66HX4K4CO

141549

DTXSID2037186

2935009090

88.7

2.85 @ pH 7.4

red to brown powder

197-199 °C

563ºC at 760 mmHg

294.3ºC

DMSO: 10 mg/mL with heat and sonication

Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.

Oral-mouse LD50: 181 mg/kg; intraperitoneal-mouse LD50: 20.56 mg/kg

Combustible; Decomposes by heating to release toxic nitrogen oxides, sulfur oxides and hydrogen chloride fumes

III

6.1(b)

UN 2811 6.1/PG 3

3

25-36/37/38

26-45

PB1081000

T

Warehouse ventilated, low temperature and dry

Physical stability is not significantly affected by normal temp ranges. The drug is light-sensitive. After dilution in 5% glucose at a final concn of 150 ug/ml, amsacrine is stable during exposure to diffuse daylight or fluorescent light over a 48 hr period.

P261-P301 + P310-P305 + P351 + P338

H301-H315-H319-H335

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

highly toxic

Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

AMSA