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Amtolmetin guacil

Amtolmetin guacil structure

CAS No:
87344-06-7
Formula:
C24H24N2O5
Chemical Name:
Amtolmetin guacil
Synonyms:
Glycine,N-[2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-,2-methoxyphenyl ester;Glycine,N-[[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-,2-methoxyphenyl ester;ST 679;MED 15;Amtolmetin guacil;Amtolmethin guacil;Amtolmetin guacyl;Finrid TM;(2-Methoxyphenyl)2-[[2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetyl]amino]acetate;2-Methoxyphenyl 2-(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetamido)acetate;104076-16-6
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Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Amtolmetin guacil is a N-acyl-amino acid.

Amtolmetin guacil Basic Attributes

Molecular Weight：

420.46

Exact Mass：

420.46

UNII：

323A00CRO9

DSSTox ID：

DTXSID50236291

Characteristics

PSA：

86.6

XLogP3：

1.98

Appearance：

White needle-shaped crystal

Density：

1.2±0.1 g/cm3

Melting Point：

117-120 °C

Boiling Point：

663.3±55.0 °C at 760 mmHg

Flash Point：

354.9±31.5 °C

Refractive Index：

1.583

Toxicity：

LD50 in male mice, rats (mg/kg): 1370, 1100 i.p.; >1500, 1450 orally (Baglioni)

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

2-methoxyphenyl 1-methyl-5-(4-methylbenzoylpyrrol)-2-acetamidoacetate

Amtolmetin guacil Use and Manufacturing

Analgesic; anti-inflammatory used in the treatment of rheumatoid arthritis,

Computed Properties

Molecular Weight:420.5
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:420.16852187
Monoisotopic Mass:420.16852187
Topological Polar Surface Area:86.6
Heavy Atom Count:31
Complexity:632
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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High quality Amtolmetin Guacil CAS NO.87344-06-7

CAS No.: 87344-06-7

Grade: Pharmaceutical Grade

Content: 99%

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