Aptazapine
-
Aptazapine
structure -
-
CAS No:
71576-40-4
-
Formula:
C16H19N3
-
Chemical Name:
Aptazapine
-
Synonyms:
2H,10H-Pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine,1,3,4,14b-tetrahydro-2-methyl-;1,3,4,14b-Tetrahydro-2-methyl-2H,10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine;Aptazapine
-
CAS No:
Description
Aptazapine (CGS-7525A) was a tetracyclic antidepressant developed in the 1980s. Aptazapine had noradrenergic and specific serotonergic activity. It antagonised α2 adrenergic receptors approximately 10 times more effectively than mianserin, antagonised 5-HT2 receptors, agonised H1 receptors, and did not affect reuptake of serotonin or norepinephrine. Although Aptazapine reached clinical trials, it was never marketed.
Drug Information
Investigated for the treatment of depression.
1,3,4,14b-tetrahydro-2-methyl-10H-pyrazino-(1,2-a)pyrrolo(2,1-c)(1,4)benzodiazepine
Computed Properties
Molecular Weight:253.34
XLogP3:1.8
Hydrogen Bond Acceptor Count:2
Exact Mass:253.157897619
Monoisotopic Mass:253.157897619
Topological Polar Surface Area:11.4
Heavy Atom Count:19
Complexity:332
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes