 Home > Encyclopedia > Apilimod

Apilimod

Apilimod structure

CAS No:
541550-19-0
Formula:
C23H26N6O2
Chemical Name:
Apilimod
Synonyms:
Benzaldehyde,3-methyl-,2-[6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone;Benzaldehyde,3-methyl-,[6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone;Apilimod;STA 5326
Categories:
Organic Chemistry > Hydrazine or Hydroxylamine Derivatives

Description

Apilimod is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.

Apilimod Basic Attributes

Molecular Weight：

418.498

Exact Mass：

418.49

UNII：

GFW2K84S4L

Characteristics

PSA：

84.8 Å²

XLogP3：

3.22210

Density：

1.2±0.1 g/cm3

Flash Point：

350.0±34.3 °C

Refractive Index：

1.637

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Investigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders.

MeSH Entry Terms：

apilimod

Apilimod Use and Manufacturing

Apilimod is a small-molecule that selectively suppresses synthesis of IL-12 and IL-23. Apilimod reduces dendritic cell infiltration in psoriasis.

Computed Properties

Molecular Weight:418.5
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:418.21172409
Monoisotopic Mass:418.21172409
Topological Polar Surface Area:84.8
Heavy Atom Count:31
Complexity:544
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Apilimod

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

APILIMOD

CAS No.: 541550-19-0

Content: 99.00%

Inquiry
Greenbo Biochem Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED Intermediates

Apilimod 99% high purity certified Professional Producer Greenbo

CAS No.: 541550-19-0

Grade: Pharmaceutical Grade

Content: 99%

Inquiry