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Home > Encyclopedia > ARCYRIAFLAVIN A

ARCYRIAFLAVIN A

ARCYRIAFLAVIN A structure

ARCYRIAFLAVIN A 

structure
  • CAS No:

    118458-54-1

  • Formula:

    C20H11N3O2

  • Chemical Name:

    ARCYRIAFLAVIN A

  • Synonyms:

    12,13-dihydro-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione monohydrate;arcyriaflavin A;12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione;CHEMBL268368;LSM-3627;Arcyriaflavin A, Synthetic;STAUROSPORINE AGLYCON;BDBM2672;SCHEMBL8124103

Description

LSM-3627 is an indolocarbazole.

ARCYRIAFLAVIN A Basic Attributes

325.32

325.085

DTXSID50416132

Characteristics

77.8

3.6

1.621±0.06 g/cm3(Predicted)

>200 °C

Store at -20°C

Drug Information

12,13-dihydro-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione monohydrate

ARCYRIAFLAVIN A Use and Manufacturing

Potent inhibitor of cdk4/cyclin D1 (IC 50 = 59 nM). Also active against CaM kinase II (IC 50 = 25 nM) but displays selectivity over several other kinases in vitro (IC 50 values for inhibition of PKA and PKC are > 2 and > 100 μ M respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC 50 = 200 nM).

Computed Properties

Molecular Weight:325.3
XLogP3:3.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Exact Mass:325.085126602
Monoisotopic Mass:325.085126602
Topological Polar Surface Area:77.8
Heavy Atom Count:25
Complexity:570
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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