Arzoxifene hydrochloride

Arzoxifene hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.

Arzoxifene Hydrochloride is the hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist. In comparison to other selective estrogen receptor modulators (SERMs), arzoxifene exhibits greater bioavailability and higher anti-estrogenic potency in the breast than raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene. This agent may have beneficial effects on bone and the cardiovascular system.

Treatment of symptoms associated with uterine fibroids, endometriosis, and dysfunctional uterine bleeding; in the treatment of estrogen receptor positive recurrent/metastatic breast cancer; as an adjuvant to breast cancer therapy (selective estrogen recep.

Molecular Weight:512.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:511.1584073
Monoisotopic Mass:511.1584073
Topological Polar Surface Area:79.4
Heavy Atom Count:35
Complexity:601
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes