3-amino-5-bromopyridine-2-carboxylic acid
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3-amino-5-bromopyridine-2-carboxylic acid
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CAS No:
870997-85-6
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Formula:
C6H5BrN2O2
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Chemical Name:
3-amino-5-bromopyridine-2-carboxylic acid
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Synonyms:
3-amino-5-bromopyridine-2-carboxylic acid;3-Amino-5-bromopyridine-2...;3-Amino-5-bromopicolinic acid;3-AMino-5-broMopyridin-2-carboxylic acid;3-AMino-5-broMopyridine-2-carboxylic;2-Pyridinecarboxylic acid, 3-aMino-5-broMo-;3-amino-5-bromo-2-Pyridinecarboxylic acid
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CAS No:
3-amino-5-bromopyridine-2-carboxylic acid Basic Attributes
217.03
215.953430
DTXSID10678395
2933399090
3-amino-5-bromopyridine-2-carboxylic acid Use and Manufacturing
Step 2: 3-Amino-5-bromo-pyridine-2-carboxylic acid To a 100 mL round bottom flask, 3-amino-5-bromo-pyridine-2-carboxylic acid amide (1.05 g, 0.0049 mol) and aqueous sodium hydroxide solution (0.98 g in 10 mL water, 0.0245 mol) was added. The reaction mixture was stirred at reflux temperature for 5 h. The volatiles were evaporated under reduced pressure to get the residue. The residue was neutralized to pH = 7.0, using 2N HC1 at 0°C to obtain the precipitate. The precipitate was filtered and dried to get the title compound as light yellow solid [1 g, 95percent]. 1H NMR (300 MHz, DMSO-dTo a 100 mL round bottom flask, 3-amino-5-bromo-pyridine-2-carboxylic acid amide (1.05 g, 0.0049 mol) and aqueous sodium hydroxide solution (0.98 g in 10 mL water, 0.0245 mol) were added. The reaction mixture was stirred at reflux temperature for 5 hours. The volatiles were evaporated under reduced pressure to provide the residue. The residue was neutralized to pH 7.0, using 2N HCl at 0° C. to obtain the precipitate. The precipitate was filtered and dried to provide the title compound as light yellow solid (1 g, 95percent). (5) Production of 3-amino-5-bromopyridine-2-carboxylic acid: 3-Amino-5-bromopyridine-2-carboxamide (216 mg, 1.0 mmol) was dissolved in concentrated hydrochloric acid (3 mL), and stirred at 100°C for 20 hours. After cooled to 0°C, water (10 mL) was added to it and controlled to have a pH of 7 with sodium hydrogencarbonate solution added thereto. The resulting gray solid was taken out through filtration and dried to obtain the intended compound (119 mg, 55 percent).A mixture of
Computed Properties
Molecular Weight:217.02
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:215.95344
Monoisotopic Mass:215.95344
Topological Polar Surface Area:76.2
Heavy Atom Count:11
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3-amino-5-bromopyridine-2-carboxylic acid
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