Carboxyamidotriazole
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Carboxyamidotriazole
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CAS No:
99519-84-3
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Formula:
C17H12Cl3N5O2
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Chemical Name:
Carboxyamidotriazole
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Synonyms:
1H-1,2,3-Triazole-4-carboxamide,5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-;5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide;L 651582;NSC 609974;CAI;Carboxyamidotriazole;197445-54-8
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CAS No:
Description
Carboxyamidotriazole (L 651582; CAI) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2].
Carboxyamidotriazole has been used in trials studying the treatment of Lymphoma, Lung Cancer, Breast Cancer, Kidney Cancer, and Ovarian Cancer, among others.|Carboxyamidotriazole is an orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores and resulting in the disruption of calcium channel-mediated signal transduction and inhibition of vascular endothelial growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This agent may also inhibit tumor cell growth, invasion and metastasis. (NCI04)
Characteristics
117
4.48020
white to beige
1.65g/cm3
200-202 °C
685.5ºC at 760 mmHg
368.3ºC
1.73
DMSO: soluble 10mg/mL (clear solution)
Store at +4°C
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)
4-CAI
Carboxyamidotriazole Use and Manufacturing
Carboxyamidotriazole is an orally active calcium channel blocker. Carboxyamidotriazole also exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages as potential anti-cancer mechanism.
Computed Properties
Molecular Weight:424.7
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:423.005658
Monoisotopic Mass:423.005658
Topological Polar Surface Area:117
Heavy Atom Count:27
Complexity:549
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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