3-Amino-4-nitrobenzoic acid

A mixture of 3-amino-4-nitro-benzonitrile (1.2g, 7.36 mmol), concentrated HC1 (50 mL), and water (100 mL) was heated to reflux for 2 days. Cooled to room temperature and collected orange solid by filtration. Washed solid with water until wash was neutral, to provide 1.11 g (83percent) of 3-amino-4-nitro-benzoic acid.Step S21: dissolving compound a in water, then adding a 30% hydrochloric acid solution, adding crushed ice to a mass concentration of 8-12%, and adding 30% sodium nitrite solution to make the pH of the reaction solution <2 After the potassium iodide test paper is immersed, it is slightly blue, T=0-10 C., and the reaction is 1-3 hours. The excess sodium nitrite is removed by using sulfamic acid, and the diazo solution described in step S21 is obtained.Step S22: The compound d is neutralized with a 10%-20% sodium hydroxide solution to pH=6.0-7.0, and all of them are dissolved, and added to the diazo solution in step S21, T=0-10 C, and the reaction is 2-4 h. Reacting the alkaline coupling solution described in step S22;Step S23: dissolving compound e in water, then adding 30% hydrochloric acid solution, adding crushed ice to make a mass concentration of 8-12%, and adding 30% sodium nitrite solution to make pH<2 in the reaction solution. The potassium iodide test paper is slightly blue after immersion, T=0-10 C, the reaction is 1-3 h, and excess sodium nitrite is removed with sulfamic acid to obtain the diazo liquid described in step S22;Step S24: adding the diazo solution obtained in the step S22 to the alkaline coupling solution, adjusting the pH of the solution with a soda ash to 5.5-6.5, T=0-10 C, and maintaining the dye for the chemical structural formula 3-5. The chemical structural formula 3-5 is as follows:Step S25: 10-20% of the salt is added to the dye solution obtained in the step S24, and after the solid is completely precipitated, it is added to a solid-liquid separator for separation, the filtrate is removed, and the filter cake is collected. The filter cake was dissolved in water to a mass concentration of 5-10% to obtain a purified dye solution of the step S25.Step S26: The dye solution purified in the step S25 is desalted and concentrated by a desalting machine to make the wastewater conductivity = 0.5-1 ms/cm, and concentrated to 20-25% to obtain the dye concentrate obtained in the step S26.Step S21: dissolving compound a-1 in water, then adding a 30% hydrochloric acid solution, adding crushed ice to a mass concentration of 8-12%, and adding 30% sodium nitrite solution to adjust the pH in the reaction solution. <2, the potassium iodide test paper is slightly blue after immersion, T=0-10 C, reaction 1-3h, remove excess sodium nitrite with sulfamic acid, and react to obtain the diazo solution described in step S21, Step S22: The compound d is neutralized with a 10%-20% sodium hydroxide solution to pH=6.0-7.0, and all of them are dissolved, and added to the diazo solution in step S21, T=0-10 C, and the reaction is 2-4 h. Reacting the alkaline coupling solution described in step S22;Step S23: dissolving compound e in water, then adding 30% hydrochloric acid solution, adding crushed ice to make a mass concentration of 8-12%, and adding 30% sodium nitrite solution to make pH<2 in the reaction solution. The potassium iodide test paper is slightly blue after immersion, T=0-10 C, the reaction is 1-3 h, and excess sodium nitrite is removed with sulfamic acid to obtain the diazo liquid described in step S22;Step S24: adding the diazo solution obtained in the step S22 to the alkaline coupling solution, adjusting the pH of the solution with a soda ash to 5.5-6.5, T=0-10 C, and maintaining the dye for the chemical structural formula 3-1. The chemical structural formula 3-1 is as follows:Step S25: 10-20% of the salt is added to the dye solution obtained in the step S24, and after the solid is completely precipitated, it is added to a solid-liquid separator for separation, the filtrate is removed, and the filter cake is collected. The filter cake was dissolved in water to a mass concentration of 5-10% to obtain a purified dye solution of the step S25.Step S26: The dye solution purified in the step S25 is desalted and concentrated by a desalting machine to make the wastewater conductivity = 0.5-1 ms/cm, and concentrated to 20-25% to obtain the dye concentrate obtained in the step S26.

Molecular Weight:182.13
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:182.03275668
Monoisotopic Mass:182.03275668
Topological Polar Surface Area:109
Heavy Atom Count:13
Complexity:225
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes