1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
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1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
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CAS No:
214147-48-5
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Formula:
C7H15ClN2O
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Chemical Name:
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
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Synonyms:
1-Acetylpiperidin-4-amine hydrochloride;1-Acetyl-4-aminopiperidine hydrochloride;1-Acetyl-4-aminopiperidine hyd;1-(4-AMino-1-piperidinyl)-ethanone HCl;1-(4-Aminopiperidin-1-yl)ethanone hydrochloride;1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL;1-(4-aminopiperidin-1-yl)ethan-1-one hydrochloride
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CAS No:
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Basic Attributes
178.6598
178.087296
1806241-263-5
DTXSID00589421
2933399090
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38
24/25-26-36/37
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Use and Manufacturing
A solution of iert-butyl (1-acetylpiperidin-4-yl)carbamate I7 (10.72 g, 44.24 mmol) in 1 , 4- dioxane (100 mL) was cooled to 0 °C and treated with 4.0 M HCI in 1 , 4-dioxane (12.2 mL, 48.7 mmol). A white precipitate formed following addition of the acid which was isolated by filtration. The precipitate was dissolved in MeOH (100 mL) and treated with 4.0 M HCI in 1 , 4- dioxane (12.2 mL, 48.7 mmol) and the mixture was stirred at room temperature for 16 hours. Another aliquot of 4.0 M HCI in 1 , 4-dioxane (6.10 mL, 24.4 mmol) was added and the reaction mixture was stirred for 1 .5 hours at 40 C. The volatiles were removed in vacuo and the white solid was dried under high vacuum to give the title compound (8.60 g, -90percent purity, >95percent yield). To a solution of ie -butyl (1 -acetylpiperidin-4-yl)carbamate I43 (2.5 g, 10 mmol) in MeOH (10 mL) was added HCI/EtOAc (2 M, 10 mL). The mixture was stirred at room temperature overnight. The solvent was removed to give the desired compound (1.6 g, 89percent yield) as a white solid. LCMS-C: RT 0.25 min; m/z 143.1 [M+H] (free base)
Computed Properties
Molecular Weight:178.66
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:178.0872908
Monoisotopic Mass:178.0872908
Topological Polar Surface Area:46.3
Heavy Atom Count:11
Complexity:128
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
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