Amphotericin B monomethyl ester
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Amphotericin B monomethyl ester
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CAS No:
36148-89-7
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Formula:
C48H75NO17
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Chemical Name:
Amphotericin B monomethyl ester
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Synonyms:
Amphotericin B,methyl ester;14,39-Dioxabicyclo[33.3.1]nonatriacontane,amphotericin B deriv.;Amphotericin B monomethyl ester;37698-54-7
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CAS No:
Description
Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].
Amphotericin B methyl ester is the methyl ester of amphotericin B. It has a role as an antifungal agent, an antiinfective agent and a metabolite. It is a macrolide, a monosaccharide derivative and a methyl ester. It derives from an amphotericin B.
Drug Information
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)
AME
Amphotericin B monomethyl ester Use and Manufacturing
Amphotericin B Methyl Ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B Methyl Esterin is a cholesterol binding compound that showed inhibiton of human immunodeficiency virus type 1 (HIV-1).
Computed Properties
Molecular Weight:938.1
XLogP3:2.6
Hydrogen Bond Donor Count:11
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:4
Exact Mass:937.50349992
Monoisotopic Mass:937.50349992
Topological Polar Surface Area:309
Heavy Atom Count:66
Complexity:1680
Defined Atom Stereocenter Count:19
Defined Bond Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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