Amphomycin
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Amphomycin
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CAS No:
1402-82-0
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Chemical Name:
Amphomycin
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Synonyms:
Amphomycin;Amfomycin;Glumamycin;11006-01-2;37265-41-1
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CAS No:
Characteristics
506.84000
0.52660
1.0985 (rough estimate)
854.06°C (rough estimate)
977.9ºC
1.6700 (estimate)
Oral-mouse LD50: 500 mg/kg; intraperitoneal-mouse LD50: 233 mg/kg
Flammable; heat produces toxic nitrogen oxide fumes
D25 +7.5° (c = 1 at pH 6)
Amphomycin Use and Manufacturing
Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is active against Gram positive bacteria, inhibiting peptidoglycan synthesis and blocking cell wall development. Amphomycin is closely related to a number of “lost” antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.
Computed Properties
Molecular Weight:1290.4
XLogP3:-2.9
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:21
Rotatable Bond Count:22
Exact Mass:1289.65033234
Monoisotopic Mass:1289.65033234
Topological Polar Surface Area:507
Heavy Atom Count:91
Complexity:2710
Defined Atom Stereocenter Count:11
Undefined Atom Stereocenter Count:2
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes