ANGIOTENSINOGEN
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ANGIOTENSINOGEN
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CAS No:
20845-02-7
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Formula:
C85H123N21O20
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Chemical Name:
ANGIOTENSINOGEN
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Synonyms:
ANGIOTENSINOGEN;ANGIOTENSINOGEN (1-14) (HORSE);ANGIOTENSINOGEN (1-14), PORCINE;ANGIOTENSINOGEN FRAGMENT 1-14 PORCINE;H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH;ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER;PREANGIOTENSINOGEN (1-14) (HORSE);RENIN SUBSTRATE
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CAS No:
Description
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
Drug Information
Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES. (See all compounds classified as Serine Proteinase Inhibitors.)
Angiotensinogen
Computed Properties
Molecular Weight:1759.0
XLogP3:0.8
Hydrogen Bond Donor Count:23
Hydrogen Bond Acceptor Count:24
Rotatable Bond Count:52
Exact Mass:1757.92532540
Monoisotopic Mass:1757.92532540
Topological Polar Surface Area:650
Heavy Atom Count:126
Complexity:3610
Undefined Atom Stereocenter Count:15
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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