APC 366
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APC 366
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CAS No:
178925-65-0
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Formula:
C22H28N6O4
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Chemical Name:
APC 366
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Synonyms:
APC 366;APC-366;N-(1-hydroxy-2-naphthoyl)-Arg-Pro-NH2;N-(1-hydroxy-2-naphthoyl)arginyl-prolinamide;TGP1HP0WBC;UNII-TGP1HP0WBC;L-Prolinamide, N2-((1-hydroxy-2-naphthalenyl)carbonyl)-L-arginyl-, monohydrochloride;apc366
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CAS No:
APC 366 Use and Manufacturing
Selective inhibitor of mast cell tryptase (K i = 7.1 μ M) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo .
Computed Properties
Molecular Weight:477.0
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:476.1938811
Monoisotopic Mass:476.1938811
Topological Polar Surface Area:177
Heavy Atom Count:33
Complexity:725
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes