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ARP100

ARP100 structure

CAS No:
704888-90-4
Formula:
C17H20N2O5S
Chemical Name:
ARP100
Synonyms:
ARP100;N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide;2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide;MMP-2 Inhibitor III;N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide
Categories:
Organic Chemistry > Amides

Description

ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2].

ARP100 Basic Attributes

Molecular Weight：

364.42

Exact Mass：

364.109283

DSSTox ID：

DTXSID30434718

HScode：

2935009090

Characteristics

PSA：

104.32000

XLogP3：

2.08

Density：

1.3±0.1 g/cm3

Refractive Index：

1.589

Water Solubility：

soluble at 100mM in DMSO

Storage Conditions：

Desiccate at +4°C

Drug Information

MeSH Entry Terms：

ARP-100

Computed Properties

Molecular Weight:364.4
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:364.10929292
Monoisotopic Mass:364.10929292
Topological Polar Surface Area:104
Heavy Atom Count:25
Complexity:518
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes