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Ataciguat

Ataciguat structure

CAS No:
254877-67-3
Formula:
C21H19Cl2N3O6S3
Chemical Name:
Ataciguat
Synonyms:
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide;ataciguat;HMR 1766;HMR-1766;HMR1766;UNII-QP166M390Q;5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-(4-morpholin-4-ylsulfonylphenyl)benzamide;QP166M390Q
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Ataciguat has been investigated for the basic science of Aortic Valve Stenosis.

Ataciguat Basic Attributes

Molecular Weight：

576.5

Exact Mass：

574.981323

UNII：

QP166M390Q

DSSTox ID：

DTXSID7048746

Characteristics

PSA：

167

XLogP3：

6.08

Density：

1.6±0.1 g/cm3

Refractive Index：

1.685

Drug Information

MeSH：

Compounds or factors that act on a specific enzyme to increase its activity. (See all compounds classified as Enzyme Activators.)

MeSH Entry Terms：

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide

Ataciguat Use and Manufacturing

Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC.Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes.Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.

Computed Properties

Molecular Weight:576.5
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:574.9813042
Monoisotopic Mass:574.9813042
Topological Polar Surface Area:167
Heavy Atom Count:35
Complexity:944
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Best Price Pure 98% HPLC HMR-1766 Solid Ataciguat CAS 254877-67-3

CAS No.: 254877-67-3

Grade: Pharmaceutical Grade

Content: 98%

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