Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1)
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Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1)
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CAS No:
649749-10-0
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Formula:
C5H14NO.1/2MoS4
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Chemical Name:
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1)
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Synonyms:
Ethanaminium,2-hydroxy-N,N,N-trimethyl-,(T-4)-tetrathioxomolybdate(2-) (2:1);ATN 224;Bis(choline) tetrathiomolybdate;WTX 101;Tiomolibdate Choline;ALXN 1840;2-hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate (2:1)
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CAS No:
Description
Tiomolibdate Choline is an orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. Tiomolibdate choline selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis.
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1) Basic Attributes
432.54152
436.024
FD57A79R4P
C62514
Drug Information
Treatment of Wilson Disease
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (See all compounds classified as Angiogenesis Inhibitors.)|Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
ammonium tetrathiomolybdate
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1) Use and Manufacturing
Human Drugs -> EU pediatric investigation plans
Computed Properties
Molecular Weight:434.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:436.024417
Monoisotopic Mass:436.024417
Topological Polar Surface Area:107
Heavy Atom Count:19
Complexity:65.7
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
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Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1)
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