ATL 146e
-
ATL 146e
structure -
-
CAS No:
250386-15-3
-
Formula:
C23H30N6O6
-
Chemical Name:
ATL 146e
-
Synonyms:
ATL 146e;Apadenoson;BMS 068645;DWH 146e;trans-4-[3-[6-Amino-9-(N-ethyl--D-ribofuranuronamidosyl)-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester;APADENOSON, ATL146-e;Apadenoson(Discontinued);Apadenoson,BMS-068645, ATL-146e, DWH-146e
-
CAS No:
Description
Apadenoson is a selective A2a adenosine receptor agonist designed for use as a pharmacologic stress agent in cardiac perfusion imaging studies. It is developed by Bristol-Myers Squibb and is in phase II of clinical trials.
Drug Information
Investigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified).
BMS068645 is designed to selectively stimulate the A2a adenosine receptor responsible for coronary vasodilation. Research to date suggests that this compound could potentially reduce or eliminate side effects associated with currently available pharmacologic stress agents that are not selective for the A2a adenosine receptor.
4-(3-(6-amino-9-(5-ethylcarbamoyl-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)prop-2-ynyl)cyclohexanecarboxylic acid methyl ester
ATL 146e Use and Manufacturing
An A2A adenosine receptor agonist. Adjunct to nuclear myocardial perfusion imaging in patients unable to exercise adequately
Computed Properties
Molecular Weight:486.5
XLogP3:0.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:486.22268270
Monoisotopic Mass:486.22268270
Topological Polar Surface Area:175
Heavy Atom Count:35
Complexity:839
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes