Azimexone
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Azimexone
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CAS No:
64118-86-1
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Formula:
C9H14N4O
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Chemical Name:
Azimexone
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Synonyms:
2-Aziridinecarboxamide,1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]-;1-[1-(2-Cyano-1-aziridinyl)-1-methylethyl]-2-aziridinecarboxamide;BM 12531;Azimexon;Azimexone
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CAS No:
Description
Azimexon is azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T lymphocyte transformation and phagocytosis. The mode of action of azimexon is unknown. It has been suggested that azimexon may alkylate DNA. In cancer patients it increases leukocytosis, blood active T rosettes, T4/T8 ratio, and is used as an adjuvant to chemotherapy in the treatment of melanoma and myeloma.
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)
2-(2-cyanaziridinyl-(1))-2-(2-carbamoylaziridinyl-(1))propane
Computed Properties
Molecular Weight:194.23
XLogP3:-0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:194.11676108
Monoisotopic Mass:194.11676108
Topological Polar Surface Area:72.9
Heavy Atom Count:14
Complexity:329
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes