AZIRIDINE TRIMER
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AZIRIDINE TRIMER
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CAS No:
23435-23-6
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Formula:
C6H15N3
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Chemical Name:
AZIRIDINE TRIMER
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Synonyms:
N-(2-Aminoethyl)-1-aziridineethanamine;N"-[2-(aziridin-1-yl)ethyl]ethane-1,2-diamine;UNII-K93WMR7E2S;K93WMR7E2S;CHEMBL398940;N-(2-((2-Aminoethyl)amino)ethyl)aziridine;Aziridine, 1-(2-((2-aminoethyl)amino)ethyl)- (8CI);N-(2-aminoethyl)-1-aziridine-ethanamine;N-[2-[(2-Aminoethyl)amino]ethyl]aziridine;NSC174041
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CAS No:
Description
N-(2-aminoethyl)-1-aziridine-ethanamine is a primary amino compound that is ethane-1,2-diamine in which the hydrogen on one of the amino groups is replaced by a 2-(aziridin-1-yl)ethyl group. It is a angiotensin-converting enzyme 2 (ACE2) inhibitor and a potential therapeutic agent for treating SARS coronavirus infections. It has a role as an EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor and an anticoronaviral agent. It is a member of aziridines, a secondary amino compound and a primary amino compound. It derives from a diethylenetriamine.|First described in the literature in 2004, N-(2-Aminoethyl)-1-aziridineethanamine is an experimental angiotensin converting enzyme 2 inhibitor investigated for its use in treating cardiovascular disease and its activity against Severe Acute Respiratory Syndrome (SARS).
Drug Information
This experimental drug was being researched for its use in the treatment of cardiovascular disease and SARS-CoV infections.
Angiotensin II constricts coronary blood vessels and is positively inotropic, which under normal circumstances, would increase vascular resistance and oxygen consumption. This action can eventually lead to myocyte hypertrophy and vascular smooth muscle cell proliferation. N-(2-Aminoethyl)-1-aziridineethanamine may inhibit ACE2, preventing these actions from occurring. N-(2-Aminoethyl)-1-aziridineethanamine binding to ACE2 may lead to a conformational change in ACE2, shifting the residues that would bind SARS-CoV S-glycoprotein, preventing viral attachment and entry.
Computed Properties
Molecular Weight:129.20
XLogP3:-1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:129.126597491
Monoisotopic Mass:129.126597491
Topological Polar Surface Area:41.1
Heavy Atom Count:9
Complexity:70.7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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