Proparacaine hydrochloride
-
Proparacaine hydrochloride
structure -
-
CAS No:
5875-06-9
-
Formula:
C16H26N2O3.ClH
-
Chemical Name:
Proparacaine hydrochloride
-
Synonyms:
Benzoic acid,3-amino-4-propoxy-,2-(diethylamino)ethyl ester,hydrochloride (1:1);Benzoic acid,3-amino-4-propoxy-,2-(diethylamino)ethyl ester,monohydrochloride;2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride;Ophthaine hydrochloride;Proparacaine hydrochloride;2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride;Ophthain;Alcaine;Chibro-keracaine;Ophthetic;Fluoracaine;Ak-Taine;Paracaine
- Categories:
-
CAS No:
Description
Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.
Proparacaine hydrochloride Basic Attributes
330.85
330.171021
227-541-7
U96OL57GOY
759896
DTXSID0049022
C47693
2922504500
Safety Information
NONH for all modes of transport
3
20/21/22-36-43
26-36
DG3065000
Xn
P280-P305 + P351 + P338
H302-H312-H317-H319-H332
|Warning|H302 (97.62%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P333+P313, P337+P313, P363, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
Proparacaine hydrochloride Use and Manufacturing
Anesthetic;Neuronal conductance inhibitor
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Computed Properties
Molecular Weight:330.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:330.1710204
Monoisotopic Mass:330.1710204
Topological Polar Surface Area:64.8
Heavy Atom Count:22
Complexity:295
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Topical anesthetics
Registered Holders
-
Suzhou Lezhu Pharmaceutical Co., Ltd.
Active
China
-
Shenlong Medicine (Changshu) Co., Ltd.
Active
China
-
Younitel Nanjing Pharmaceutical Co., Ltd.
Active
China
Recommended Suppliers of Proparacaine hydrochloride
-
![China]()
CN
3 YRS
Business licensedTrader Supplier of vitaminInquiryCAS No.: 5875-06-9Grade: Food gradeContent: 99% -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamine -
![China]()
CN
3 YRS
Business licensedTrader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVEInquiryCAS No.: 5875-06-9Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
2 YRS
Business licensedTrader Supplier of Propylene glycolInquiryCAS No.: 5875-06-9Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
4H-1-Benzopyran-4-one, 2-[4-[3-(dibutylamino)propoxy]-3,5-dimethylbenzoyl]-, hydrochloride (1:1)
67652-33-9
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)
681807-60-3
-
CYCLOPENTYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE HYDROCHLORIDE
1052525-88-8
-
2-Cyclopropylbenzenemethanamine hydrochloride Formula
118184-64-8
-
Des[4-(2-cycloproylMethoxy)] Betaxolol Hydrochloride Formula
464877-45-0
-
Ethanamine, 2-(decylthio)-, hydrochloride (1:1) Formula
36362-09-1
-
4,7-Dichloro-2-propylquinoline hydrochloride Structure
1204812-22-5
-
6,7-Dichloro-4-hydrazino-2-methylquinoline hydrochloride Structure
1170377-12-4
-
What is 2,8-Diazaspiro[4.5]decan-1-one, 2-[(4-bromophenyl)methyl]-, hydrochloride (1:1)
832710-56-2
-
What is 6,7-Dichloro-4-hydrazinoquinoline hydrochloride
1171843-02-9