Mepivacaine hydrochloride
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Mepivacaine hydrochloride
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CAS No:
1722-62-9
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Formula:
C15H22N2O.ClH
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Chemical Name:
Mepivacaine hydrochloride
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Synonyms:
2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-,hydrochloride (1:1);2′,6′-Pipecoloxylidide,1-methyl-,monohydrochloride;2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-,monohydrochloride;Carbocaine monohydrochloride;Mepivacaine monohydrochloride;Mepivacaine hydrochloride;Carbocaine hydrochloride;Scandonest;(±)-Mepivacaine hydrochloride;Scandicain;Polocaine;Mepident;Meaverin;Mepicaton;Chlorocain;Optocain;Carbocaina;Mepivastesin;16452-56-5;38423-99-3
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CAS No:
Description
White SolidChEBI: The hydrochloride salt of mepivacaine. It is used as a local anaesthetic.
Mepivacaine hydrochloride is the hydrochloride salt of mepivacaine. It is used as a local anaesthetic. It has a role as a local anaesthetic. It is a piperidinecarboxamide and a hydrochloride. It derives from a mepivacaine.|A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Mepivacaine hydrochloride Basic Attributes
282.81
282.149902
217-023-9
758674
DTXSID4031566
29333990
Characteristics
32.3
3.53910
white to beige
262-264 °C
383.1ºC at 760 mmHg
185.5ºC
H2O: soluble20mg/mL, clear
Refrigerator
4.52E-06mmHg at 25°C
Abdominal cavity-mouse LD50: 117 mg/kg; intravenous-mouse LD50: 35 mg/kg
Thermal decomposition to emit toxic nitrogen oxide fumes
157.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
UN 2811 6.1 / PGIII
22
22-24/25
TK6475000
Xn
The warehouse is low-temperature, ventilated and dry
P301 + P310
H301
|Danger|H301 (65%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P301+P312, P321, P330, P405, and P501|Aggregated GHS information provided by 60 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)
Carbocaïne
Mepivacaine hydrochloride Use and Manufacturing
An anti-inflammatory and analgesic
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, hydrochloride (1:1): ACTIVE
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Computed Properties
Molecular Weight:282.81
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:282.1498911
Monoisotopic Mass:282.1498911
Topological Polar Surface Area:32.3
Heavy Atom Count:19
Complexity:282
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Local anesthetic effect
Registered Holders
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Jining Shenzhou Pharmaceutical Co., Ltd.
Active
China
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SOCIETA ITALIANA MEDICINALI SCANDICCI SIMS SRL
Active
United States
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Pcas
Active
United States
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