 Home > Encyclopedia > Articaine hydrochloride

Articaine hydrochloride

Articaine hydrochloride structure

CAS No:
23964-57-0
Formula:
C13H20N2O3S.ClH
Chemical Name:
Articaine hydrochloride
Synonyms:
2-Thiophenecarboxylic acid,4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-,methyl ester,hydrochloride (1:1);2-Thiophenecarboxylic acid,4-methyl-3-[2-(propylamino)propionamido]-,methyl ester,monohydrochloride;2-Thiophenecarboxylic acid,4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-,methyl ester,monohydrochloride;Methyl 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate hydrochloride;Carticaine hydrochloride;Ultracaine;Ultracain;HOE 045;Carticain;Articaine hydrochloride;Septanest;HOE 40045;Ultacain;Carticaine chlorhydrate;Ubistesine
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Request for Quotation

Description

White or almost white, crystalline powder.

Articaine hydrochloride Basic Attributes

Molecular Weight：

320.832

Exact Mass：

320.096

EC Number：

245-957-7

HScode：

2934990002

Characteristics

PSA：

95.7

XLogP3：

3.43560

Appearance：

White crystalline powder

Density：

1.178 g/cm3

Melting Point：

177-178 °C

Boiling Point：

440.6ºC at 760 mmHg

Flash Point：

220.3ºC

Vapor Pressure：

5.79E-08mmHg at 25°C

Toxicity：

LD50 i.v. in mice: 37 mg/kg (Muschaweck, Rippel)

Safety Information

wgk germany：

safety instructions：

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

Articaine hydrochloride Use and Manufacturing

Anesthetic;Na+ channel inhibitor

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Articaine Hydrochloride
Manufacturer	Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Articaine Epinephrine Injection
Ingredients	This product is a compound preparation, and its components are: each 1.7ml tube contains 68mg of articaine hydrochloride and 17μg of epinephrine tartrate (calculated as epinephrine). Excipients: sodium chloride, sodium metabisulfite, hydrochloric acid, sodium hydroxide, water for injection.
Indication	Co-administration is not recommended due to the presence of adrenaline: Sibutramine Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Caution is required when co-administered due to the presence of adrenaline ◆ Volatile halogenated anesthetics Severe ventricular arrhythmias (increased cardiac response). Limit the dose, for example: less than 0.1 mg in 10 minutes or less than 0.3 mg of adrenaline in 1 hour for adults. ◆ Imipramine-type antidepressants Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Limit the dose, for example: less than 0.1 mg in 10 minutes or less than 0.3 mg of adrenaline in 1 hour for adults. ◆ Serotonergic-noradrenergic antidepressants (Misipram and Venlafaxine) Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Limit dose, e.g., less than 0.1 mg in 10 minutes or less than 0.3 mg of epinephrine in 1 hour for adults. ◆ Non-selective MAO inhibitors (iproniazid) generally increase the pressor effect of epinephrine moderately. Use only under close clinical supervision ◆ Type "A" selective MAO inhibitors (moclobemide, toloxatone) derived from non-selective MAO inhibitors present a risk of increasing the pressor effect of epinephrine. Use only under close clinical supervision Guanethidine can significantly increase blood pressure (due to decreased sympathetic tone leading to increased reactivity and/or inhibition of epinephrine or norepinephrine entry into sympathetic nerve fibers). If co-administration is unavoidable, use low doses of the sympathomimetic (epinephrine) with caution.
Specifications	1.7 ml: Articaine hydrochloride 68 mg and epinephrine tartrate 17 micrograms (calculated as epinephrine)

Compound Articaine Hydrochloride Injection
Ingredients	This product is a compound preparation, and its components are articaine hydrochloride and epinephrine. The chemical name of articaine hydrochloride is 4-methyl-3-[[1-oxo-2-(propylamino)-propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride. Its structural formula is: Molecular formula: C13H20N2O3S, HCl molecular weight: 320.84 The chemical name of epinephrine hydrochloride is: (R)-4-[1-hydroxy-2-(methylamino)-ethyl]-1,2-benzenediol. Its structural formula is: Molecular formula: C9H13NO3, HCl molecular weight: 219.67
Indication	Co-administration is not recommended due to the presence of adrenaline: .Guanethidines (for glaucoma) Significant increase in blood pressure (due to decreased sympathetic tone leading to increased reactivity and/or inhibition of adrenaline entry into sympathetic nerve fibers) If co-administration is unavoidable, use sympathomimetics (adrenaline) with caution at low doses. Use with caution due to the presence of adrenaline .Volatile halogenated anesthetics Severe ventricular arrhythmias (increased cardiac response). Use with caution: Limit dose, e.g. less than 0.1 mg in 10 minutes or less than 0.3 mg of adrenaline in 1 hour in adults. .Imipramine antidepressants Paroxysmal hypertension may be associated with arrhythmias (inhibition of adrenaline or noradrenaline entry into sympathetic nerve fibers). Use with caution: e.g. adults 10 minutes
Specifications	1.7ml: Articaine hydrochloride 68mg, epinephrine 17μg
Manufacturer	Ma'anshan Fengyuan Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

ZENTIVA KS

United States
Active
SIEGFRIED EVIONNAZ SA

France
Active
Taige Kanglihua (Beijing) Consulting Services Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Articaine hydrochloride

XI'AN YI HANG CHEMICAL CO.,LTD Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Food Additives,Active Pharm Ingredients,Chem & Pharm Intermediates,Organic Intermediates

High Quality 99% Artecain hydrochlorid,CAS # 23964-57-0 from Certified Professional Producer

Unit Price: $11-12 /KG FOB

CAS No.: 23964-57-0

Grade: Top Grade

Content: 99%

Inquiry
Hainan Flying International Trade Co., L Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of vitamin

Good Quality Articaine HCL Powder Onlie with Wholesale Price 23964-57-0

CAS No.: 23964-57-0

Grade: Food grade

Content: 99%

Inquiry
Hubei Marvel-Bio Medicine Co., Ltd.-MZ Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Tris,Octorylene

Sale Pharmaceutical Articaine HCl/Hydrochloride Powder CAS 23964-57-0 Articaine Hydrochloride

Unit Price: $10-12 /KG FOB

CAS No.: 23964-57-0

Inquiry
Hubei KDG Web Science&Technology Co.,Ltd Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Peptide,API,HCG,Amino Acids,Plant Extract,Vitamin

GMP Factory Made Articaine hydrochloride CAS 23964-57-0 Cheap Price Fast Shipping

CAS No.: 23964-57-0

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals

Articaine hydrochloride

CAS No.: 23964-57-0

Grade: Industrial Grade

Content: 98%

Inquiry