BISNAFIDE
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BISNAFIDE
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CAS No:
144849-63-8
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Formula:
C32H28N6O8
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Chemical Name:
BISNAFIDE
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Synonyms:
(R,R)-2,2"-(1,2-ethanediylbis(imino(1-methyl-2,1-ethanediyl)))-bis(5-nitro-1H-benz(de)isoquinolone-1,3-(2H)-dione)dimethanesulfonate;bisnafide;DMP 840;DMP-840;NSC D640430;NSC-D640430;UNII-62H4W26906;62H4W26906;Bisnafide [INN]
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CAS No:
Description
Bisnafide is a bis-naphthalimide compound with anticancer activity. Bisnafide selectively intercalates guanine-cytosine (GC) rich regions of DNA, thereby interfering with DNA replication machinery and activity of topoisomerase II. As a result, this agent causes potent cytotoxicity.
Drug Information
(R,R)-2,2'-(1,2-ethanediylbis(imino(1-methyl-2,1-ethanediyl)))-bis(5-nitro-1H-benz(de)isoquinolone-1,3-(2H)-dione)dimethanesulfonate
Computed Properties
Molecular Weight:624.6
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:9
Exact Mass:624.19686187
Monoisotopic Mass:624.19686187
Topological Polar Surface Area:191
Heavy Atom Count:46
Complexity:1160
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes