Benzeneacetamide, 3-amino- (9CI)

A mixture of 2- (3-NITROPHENYL) acetamide (510 mg, 2. 83 mmoles), PD/C 10% (29 mg, 0.272 mmoles), dry EHTANOL was hydrogenated under 38 psi overnight. The mixture was filtered on Celite and the filtrate was evaporated to dryness. The crude product was then reacted with 2- chloroethylisocyanate as described in examples 1-12 to obtain desired product. Purified by flash chromatography on silica gel EtOH/CH2CI2 (10: 90). BYIELD : 37%. H NMR (DMSO-d6, 300MHZ) 5 : 8.17 (brs, NH, 1H), 8.12 (d, Ar, 1H, J = 8. 2Hz), 7.65 (m, Ar, 3H), 7.03 (brs, NH, 1H), 3. 68 (s, CH2, 2H), 3.45 (m, CH2, 4H).A mixture of 2- (3-NITROPHENYL) ACETAMIDE (510 mg, 2. 83 mmoles), PD/C 10% (29 mg, 0.272 mmoles), dry ehtanol was hydrogenated under 38 psi overnight. The mixture was filtered on Celite and the filtrate was evaporated to dryness. The crude product was then reacted with 2- chloroethylisocyanate as described in examples 1-12 to obtain desired product. Purified by flash chromatography on silica gel ETOH/CH2CL2 (10: 90). BYIELD : 37%.

Molecular Weight:150.18
XLogP3:-0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:150.079312947
Monoisotopic Mass:150.079312947
Topological Polar Surface Area:69.1
Heavy Atom Count:11
Complexity:147
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes