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Cyclohexanone 1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime]

Cyclohexanone 1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime] structure

CAS No:
83654-05-1
Formula:
C20H34N4O4
Chemical Name:
Cyclohexanone 1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime]
Synonyms:
Cyclohexanone,1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime];Cyclohexanone,O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime;Cyclohexanone 1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime];RHC 80267;U 57908

Description

RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC)[1][2][3][4].

N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.

Cyclohexanone 1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime] Basic Attributes

Molecular Weight：

394.51

Exact Mass：

394.51

UNII：

9VB68H5WIT

DSSTox ID：

DTXSID90232494

Characteristics

PSA：

101

XLogP3：

3.5

Appearance：

white solid

Density：

1.2±0.1 g/cm3

Melting Point：

118-121℃

Refractive Index：

1.571

Water Solubility：

DMSO: 9 mg/mL

Storage Conditions：

Store at +4°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

GW1485000

Drug Information

MeSH：

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES). (See all compounds classified as Protease Inhibitors.)

MeSH Entry Terms：

1,6-bis(cyclohexyloximinocarbonyl)hexane

Computed Properties

Molecular Weight:394.5
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:394.25800558
Monoisotopic Mass:394.25800558
Topological Polar Surface Area:101
Heavy Atom Count:28
Complexity:484
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Learn More Other Chemicals

CYCLOHEXANONE O-OXIRANYLMETHYL-OXIME

23753-42-6
Cyclohexanone

108-94-1
CYCLOHEXANONE DIALLYLACETAL

53608-84-7
CYCLOHEXANONE O-PROP-2-YNYL-OXIME Formula

174004-17-2
Cyclohexanone 2-(2,4-dinitrophenyl)hydrazone Formula

1589-62-4
Cyclohexanone oxime Formula

100-64-1

Hot Searches: ammonium sulfate formula; menadione; sodium hypochlorite sds; density of cyclooctene; 2 pentanol; non ionic tensides

Guide of Cyclohexanone 1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime]

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Learn More Other Chemicals

Cyclohexanone 1,1′-[O,O′-[1,6-hexanediylbis(iminocarbonyl)]dioxime]

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