2-(Phenylamino)benzamide

General procedure: A two-neck round bottom flask was charged with amagnetic stirrer, evacuated and backfilled with argon. 2-iodobenzamide ( 0.5mmol, 124 mg), aniline or α-substituted benzylamine (1.0 mmol), KIn this example, milligrams of 2-anilinophenylamide was prepared. Under air, anthranilamide(68.1 mg, 0.5 mmol, 1.0 eq.) And phenylboronic acid (91.4 mg, 0.75 mmol, 1.5 eq.) Were added to a reaction flask, 10.0 mL of methanol as a reaction solvent, triethylamine (35.0 μL, 0.25 mmol, 0.5 eq.) Was added to the mixed solution, and finally Cuprous chloride (7.4 mg, 0.075 mmol, 15 molpercent) was added as a catalyst and stirred for 12 hours at room temperature.After the reaction was filtered, washed with ethyl acetate, the solvent was removed by rotary evaporation and purified by column chromatography to give 2-aniline (Yellow solid); the column chromatography conditions: using 200-300 mesh size silica gel, and silica gel to be purified The mass ratio of the substance is 100: 1, the eluent is a mixture of petroleum ether and ethyl acetate, the mixture of petroleum ether: ethyl acetate Volume ratio of 3: 1.

Molecular Weight:212.25
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:212.094963011
Monoisotopic Mass:212.094963011
Topological Polar Surface Area:55.1
Heavy Atom Count:16
Complexity:236
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes