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Home > Encyclopedia > N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide

N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide

N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide structure

N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide 

structure
  • CAS No:

    1391052-76-8

  • Formula:

    C13H8Cl2F2N2O3

  • Chemical Name:

    N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide

  • Synonyms:

    Benzamide,N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxy-;N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide;3-Hydroxy-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide

Description

Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a drug which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM.

N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide Basic Attributes

349.1170264

349.12

-0

3RXV4ND32V

Characteristics

71.45000

3.37

1.6±0.1 g/cm3

397.4±42.0 °C at 760 mmHg

194.2±27.9 °C

1.626

N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide Use and Manufacturing

O-Decyclopropyl Roflumilast is an impurity of Roflumilast (R639700).

Computed Properties

Molecular Weight:349.11
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:347.9880038
Monoisotopic Mass:347.9880038
Topological Polar Surface Area:71.4
Heavy Atom Count:22
Complexity:382
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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