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Bisoxatin

Bisoxatin structure

CAS No:
17692-24-9
Formula:
C20H15NO4
Chemical Name:
Bisoxatin
Synonyms:
2H-1,4-Benzoxazin-3(4H)-one,2,2-bis(4-hydroxyphenyl)-;2H-1,4-Benzoxazin-3(4H)-one,2,2-bis(p-hydroxyphenyl)-;2,2-Bis(4-hydroxyphenyl)-2H-1,4-benzoxazin-3(4H)-one;2,2-Bis(p-hydroxyphenyl)-2H-1,4-benzoxazin-3(4H)-one;Bisoxatin;2,2-Bis(4-hydroxyphenyl)-2H-benzo[b][1,4]oxazin-3(4H)-one;Bisoxatinum
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Bisoxatin is a diarylmethane.|Bisoxatin is a stimulant laxative which increases peristalsis and inhibits absorbtion of water and ions in the intestine. It is marketed in Belgium under the tradename Wylaxine and used for the treatment of constipation and for preparation of the colon for surgical procedures.

Bisoxatin Basic Attributes

Molecular Weight：

333.343

Exact Mass：

333.34

EC Number：

241-681-6

UNII：

7C75N0L7FP

DSSTox ID：

DTXSID00170217

ATC Code：

A06AB09|A - Alimentary tract and metabolism

HScode：

2934999090

Characteristics

PSA：

78.8

XLogP3：

3.51050

Density：

1.368±0.06 g/cm3(Predicted)

Melting Point：

284 °C

Boiling Point：

609.0±55.0 °C(Predicted)

Flash Point：

322.1ºC

Refractive Index：

1.674

Vapor Pressure：

1.99E-15mmHg at 25°C

Drug Information

Drug Indication：

For use in the treatment of constipation in the absence of bowel obstruction and for surgical preparation of the colon.

Pharmacology：

Bisoxatin is a stimulant laxative which increases peristalsis and inhibits the absorbtion of water and ions in the intestine. This increases the water content of the feces and increases its movement through the intestine.

Absorption：

Once dissociated from acetate, some bisoxatin is absorbed with a Tmax of 4 h.|Primarily excreted in the feces 48-72 h after administration as the free parent compound with a small amount remaining as the acetate salt. Bisoxatin glucuronide and a trace amount of parent compound are eliminated in the urine.

Metabolism/Metabolites：

Absorbed compound is metabolized to bisoxatin glucuronide.

Mechanism of Action：

The precise mechanism of the bisoxatin's stimulant effect and inhibition of water and ion movement is unknown.

Bisoxatin Use and Manufacturing

Laxative.

Computed Properties

Molecular Weight:333.3
XLogP3:3.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:333.10010796
Monoisotopic Mass:333.10010796
Topological Polar Surface Area:78.8
Heavy Atom Count:25
Complexity:458
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 17692-24-9

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