2-BroMo-5-iodo-1,3-diMethylbenzene

2-bromo-5-iodo1, 3-xylene (10 mmol), 9, 9-dimethyl acridine (10 mmol), Cu under a nitrogen atmosphere(20 mmol), K2CO3 (20 mmol) and N, N-dimethylformamide (20 ml) were combined to form a solution.Mixing the above mixed solution with nitrogenThe vacuum was evacuated three times and heated and stirred at 130 C for 24 h. The reaction mixture was filtered through celite and usedWash with dichloromethane (20 ml).The solvent was evaporated under reduced pressure and purified by column chromatography (hexane/dichloromethane: 10:1) to yield white crystals of 9-(4-bromo-3, 5-dimethylphenyl)-dimethyl acridine. S2-1.5.5 g (17.8 mmol) of 5.5 g (17.8 mmol) 2-Bromo-5-iodo-1 , 3-dimethylbenzene, 6.5 g (12.7 mmol) EG1 , 366 mg (0.3 mmol) tetrakis(triphenylphosphin)-palladium(0) and 2.7 g (13 mmol) sodium carbonate are dissolved in 200 ml toluene, ethanol and water (2:1 :1 ) and stirred for 16 hours at 90 C. After cooling down to room temperature 100 ml toluene are added, the organic phase is separated and washed with water (2x50 ml). The organic phase is concentrated to dryness under reduced pressure. The residue is purified by recrystallization from toluene/heptane. Yield: 6.2 g (11 mmol; 86 %)5.5 g (17.8 mmol) 2-Bromo-5-iodo-1 , 3-dimethylbenzene, 6.5 g (12.7 mmol) BB-003, 366 mg (0.3 mmol) tetrakis(thphenylphosphin)-palladium(0) and 2.7 g (13 mmol) sodium carbonate are dissolved in 200 ml toluene, ethanol and water (2:1 :1 ) and stirred for 16 hours at 90 C. After cooling to room temperature, 100 ml toluene are added, the organic phase is separated and washed with water (2x50 ml). The organic phase is concentrated to dryness under reduced pressure. The residue is purified by recrystallization from toluene/heptane. Yield: 6.2 g (11 mmol; 86 %)5.5 g (17.8 mmol) 2-Bromo-5-iodo-1 , 3-dimethylbenzene, 6.5 g (12.7 mmol) EG1 , 366 mg (0.3 mmol) tetrakis(triphenylphosphin)-palladium(0) and 2.7 g (13 mmol) sodium carbonate are dissolved in 200 ml_ toluene, ethanol and water (2:1 :1 ) and stirred for 16 hours at 90 C. After cooling down to room temperature 100 ml toluene are added, the organic phase is separated and washed with water (2 x 50 ml_). The organic phase is concentrated to dryness under reduced pressure. The residue is purified by recrystallization from toluene/heptane. Yield: 6.2 g (11 mmol; 86 %)

Molecular Weight:310.96
XLogP3:4
Exact Mass:309.88541
Monoisotopic Mass:309.88541
Heavy Atom Count:10
Complexity:104
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes