2-broMo-4,5-diMethylbenzenaMine

After measuring out 1.006 g (4.375 mmol) of 2-bromo-4, 5-dimethylnitrobenzene into a 100 mL round-bottomed flask equipped with a magnetic stirrer, 10 mL of 2-methoxyethanol and 10 mL of water were added and the mixture was stirred to create a suspension. After adding 2.799 g (10.07 mmol) of sodium hydrosulfite thereto, it was heated on a 100°C oil bath while vigorously stirring. After 2.5 hours, the resulting faint yellow suspension was heated and stirred, while adding 10 mL of water until the insoluble portion disappeared to produce a faint yellow solution. To the faint yellow solution there was added dropwise 10 mL of concentrated hydrochloric acid over a period of 5 minutes, after which the mixture was refluxed for 20 minutes. Next, the temperature of the reaction mixture was lowered to room temperature, and upon adding sodium carbonate in powder form to neutralize the reaction mixture, a faint brownish white precipitate separated at approximately pH 7-8. The collected precipitate was dried to obtain 2-bromo-4, 5-dimethylaniline as a white solid. Yield: 0.832 g (95.0percent).1H-NMR (270 MHz, CDCl3): δ2.13(6H, s), 6.59 (1H, s), 7.16(1H, s).To a solution of 3, 4-dimethylaniline (i) (30.3 g, 250 mmol) in CH

Molecular Weight:200.08
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:198.99966
Monoisotopic Mass:198.99966
Topological Polar Surface Area:26
Heavy Atom Count:10
Complexity:116
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes